Cancer diagnosis using circulating biomarkers

Authors

Keywords:

cancer biomarkers, techniques, diagnosis, clinical application

Abstract

Introduction: According to the World Health Organization, cancer is one of the main causes of mortality in the world, with more than 10 million deaths annually. Therefore, thanks to the advances in technology, researchers are seeking to develop innovative ways to reduce the morbidity and mortality of this disease through the development of multiple techniques for early detection of this pathology. Objective: describe the limitations and advantages, and the clinical application of circulating biomarkers in the diagnosis of cancer. Method: this research is of a bibliographic and descriptive nature on the Diagnosis of cancer using circulating biomarkers: review of techniques and their clinical applicability. Therefore, an initial consultation was carried out in various databases of high and medium impact scientific journals. These databases included Scielo, Dialnet Scielo, PubMed, Scopus and ElSavier. Development: predictive biomarkers provide information on the effect of a therapeutic intervention on an outcome and, therefore, offer valuable information to guide treatment decision making. Predictive biomarkers also provide information on the effect of a therapeutic intervention on the outcome and therefore offer valuable information to guide treatment decision making. Final considerations: the study of biomarkers in cancer diagnosis has proven to be a promising tool with potential clinical application.

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References

O'Brien, K., Ried, K., Binjemain, T., & Sali, A. Integrative Approaches to the Treatment of Cancer. Cancers. 2022 [citado 2024 Abr 25]; 14(23), 5933. Disponible en: https://doi.org/10.3390/cancers14235933

Kondo T. Cancer biomarker development and two-dimensional difference gel electrophoresis (2D-DIGE). Biochimica et biophysica acta. Proteins and proteomics, 2019 [citado 2024 Abr 25]; 1867(1), 2–8. Disponible en: https://doi.org/10.1016/j.bbapap.2018.07.002

Zou, J., & Wang, E. Cancer Biomarker Discovery for Precision Medicine: New Progress. Current medicinal chemistry, 2019 [citado 2024 Abr 25]; 26(42), 7655–7671. Dispoible en: https://doi.org/10.2174/0929867325666180718164712

Hristova VA, Chan DW. Cancer biomarker discovery and translation: proteomics and beyond. Expert Rev Proteomics. 2019 [citado 2024 Abr 25]; 16(2):93-103. Disponible en: https://doi:10.1080/14789450.2019.1559062

Bonifácio V. D. B. Ovarian Cancer Biomarkers: Moving Forward in Early Detection. Advances in experimental medicine and biology, 2020 [citado 2024 Abr 25]; 1219, 355–363. Disponible en : https://doi.org/10.1007/978-3-030-34025-4_18

Luo, G., Jin, K., Deng, S., Cheng, H., Fan, Z., Gong, Y., Qian, Y., Huang, Q., Ni, Q., Liu, C., & Yu, X. Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter. Biochimica et biophysica acta. Reviews on cancer, 2021 [citado 2024 Abr 25]; 1875(2), 188409.Disponible en : https://doi.org/10.1016/j.bbcan.2020.188409

Ogata, S., Masuda, T., Ito, S., & Ohtsuki, S. Targeted proteomics for cancer biomarker verification and validation. Cancer biomarkers: section A of Disease markers. 2022 [citado 2024 Abr 25]; 33(4), 427–436.Dispoible en: https://doi.org/10.3233/CBM-210218

National Guideline Alliance (UK). Colorectal cancer. National Institute for Health and Care Excellence; (update): Evidence review B1. London: National Institute for Health and Care Excellence (NICE); 2020 Jan. (NICE Guideline, No. 151.) Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK559933/2020.

Sarhadi, V. K., & Armengol, G. (). Molecular Biomarkers in Cancer. Biomolecules. 2022 [citado 2024 Abr 25]; 12(8). Disponible en: 1021. Disponible en: https://doi.org/10.3390/biom12081021

Ou F-S, Michiels S, Shyr Y, Adjei AA, Oberg AL. Biomarker discovery and validation: Statistical considerations. J Thorac Oncol [Internet]. 2021 [citado el 22 de marzo de 2024];16(4):537–45. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33545385/

Arya S, Estrela P. Recent advances in enhancement strategies for electrochemical ELISA-based immunoassays for cancer biomarker detection. Sensors (Basel) [Internet]. 2018 [citado 2024 Abr 25]; 18(7):2010. Disponible en: https://www.mdpi.com/1424-8220/18/7/2010

Dang K, Zhang W, Jiang S, Lin X, Qian A. Application of lectin microarrays for biomarker discovery. ChemistryOpen [Internet]. 2020 [citado 2024 Abr 25]; 9(3):285–300. Disponible en: http://dx.doi.org/10.1002/open.201900326

Kowalczyk T, Ciborowski M, Kisluk J, Kretowski A, Barbas C. Mass spectrometry based proteomics and metabolomics in personalized oncology. Biochim Biophys Acta Mol Basis Dis [Internet]. 2020 [citado 2024 Abr 25]; 1866(5):165690. Disponible en: http://dx.doi.org/10.1016/j.bbadis.2020.165690

Ivanov YD, Malsagova KA, Popov VP, Pleshakova TO, Kozlov AF, Galiullin RA, et al. Nanoribbon-based electronic detection of a glioma-associated circular miRNA. Biosensors (Basel) [Internet]. 2021 [citado 2024 Abr 25]; 11(7):237. Disponible en: https://www.mdpi.com/2079-6374/11/7/237

Chu Y, Gao Y, Tang W, Qiang L, Han Y, Gao J, et al. Attomolar-level ultrasensitive and multiplex microRNA detection enabled by a nanomaterial locally assembled microfluidic biochip for cancer diagnosis. Anal Chem [Internet]. 2021 [citado 2024 Abr 25]; 93(12):5129–36. Disponible en: http://dx.doi.org/10.1021/acs.analchem.0c04896

Ren X, Foster BM, Ghassemi P, Strobl JS, Kerr BA, Agah M. Entrapment of prostate cancer circulating tumor cells with a sequential size-based microfluidic chip. Anal Chem [Internet]. 2018 [citado 2024 Abr 25]; 90(12):7526–34. Disponible en: http://dx.doi.org/10.1021/acs.analchem.8b01134

Chi Z, Wu Y, Chen L, Yang H, Khan MR, Busquets R, et al. CRISPR-Cas14a-integrated strand displacement amplification for rapid and isothermal detection of cholangiocarcinoma associated circulating microRNAs. Anal Chim Acta [Internet]. 2022 [citado 2024 Abr 25]; 1205(339763):339763. Disponible en: http://dx.doi.org/10.1016/j.aca.2022.339763

Kwong GA, Ghosh S, Gamboa L, Patriotis C, Srivastava S, Bhatia SN. Synthetic biomarkers: a twenty-first century path to early cancer detection. Nat Rev Cancer [Internet]. 2021 [citado el 23 de marzo de 2024]; 21(10):655–68. Disponible en: https://www.nature.com/articles/s41568-021-00389-3

Published

2025-01-08

How to Cite

1.
Moina-Veloz Álvaro P, Maldonado-Carrasco JA, Chiluiza-Tubon DC, Ortiz-Vásquez VM. Cancer diagnosis using circulating biomarkers. Gac méd estud [Internet]. 2025 Jan. 8 [cited 2025 Jan. 22];5(3):e578. Available from: https://revgacetaestudiantil.sld.cu/index.php/gme/article/view/578

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Section

Bibliographic reviews

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